One of the earliest noticeable developmental difficulties in Jacobson syndrome is difficulty with speech and language and many of the children will require therapy well into the school‐aged years. 

Jacobsen syndrome has been linked with autism, according to a recent joint investigation by researchers therefore many of the same classroom practices used for autism many be implemented for this syndrome. 

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As for instructional strategies for the classroom that would support these learners it should be noted that a few children about 3% learn at an average pace. Leaving children with Jacobsen syndrome learning at slower rate than a majority of their classmates when in mainstream general education classrooms. It is typical that children with Jacobsen syndrome to have mild to moderate learning difficulties.

One factor that may undermine achievement is children’s typically short attention span and are easily distracted, particularly in an unstructured learning environment. It is very important for these learners that they have structure. Speaking abilities can also come later and these children may need support in using alternative means of communication. Strategies such as using picture and signing in the classroom can work well.